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pentobarbital will lower the extent or effect of ethotoin by affecting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Monitor.pentobarbital will increase effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Warning/Observe. Coadministration of ifosfamide with CYP2B6 inducers could enhance metabolism of ifosfamide to its metab